姓名：万 里
职称：研究员
导师类别：博士生导师、硕士生导师
E-mail: wanli120@126.com
一、个人基本情况
万里，男，博士，研究员，中共党员。海南大学高层次引进人才。2025年7月加入海南大学生命健康学院，成立生物大分子的组装和功能机器实验室并担任PI。
二、 教育和工作经历
万里研究员于2010年获得海南大学生物工程学士学位，于2013年获得天津大学微生物与生化药学硕士学位，2017年12月在日本京都大学获得博士学位之后，先后在美国印第安纳大学医学院、西湖大学生科院以博士后、助理研究员的身份展开科学研究，于2025年7月加入海南大学生命健康学院。
三、研究方向
本实验室主要研究方向聚焦于生物体内重要的生物大分子的结构与功能，利用分子生物学、生物化学、实验动物学及结构生物学等研究方法，从多维度阐释生命体中大分子的作用机制。研究方向但不限于包括肌营养不良症发病相关的病理学研究、病原微生物与宿主之间的交互机制、以及其他与人体重大疾病相关蛋白的作用机制。
四、代表性论文
第一作者或共同第一作者发表论文：
1. Li Wan*, Xiaofei Ge*, Qikui Xu*, Gaoxingyu Huang*, Tiandi Yang, Kevin P. Campbell, Zhen Yan, Jianping Wu. Structure and assembly of the dystrophin glycoprotein complex. Nature, 2025; 637, 1252–1260.
2. Zeyu Jin*, Li Wan*, Yuqi Zhang, Xuecheng Li, Yong Cao, Haobin Liu, Shengyao Fan, Du Cao, Zhengmao Wang, Xiaobo Li, Junmin Pan, Meng-Qiu Dong, Jianping Wu, Zhen Yan. Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes. Cell, 2022, 185(25):4788-4800.e13. (共同第一作者)
3. Jianhua Luo*, Qi Yang*, Xiaofeng Zhang*, Yuanyuan Zhang*, Li Wan*, Xiechao Zhan, Yao Zhou, Liuqing He, Danyang Li, Dazhi Jin, Ying Zhen, Jing Huang, Yanyan Li, Liang Tao. TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile. Cell, 2022, 185 (6): 980-994. (共同第一作者)
4. Li Wan, Keisuke Kamba, Takashi Nagata, Masato Katahira. An insight into the dependence of the deamination rate of human APOBEC3F on the length of single-stranded DNA, which is affected by the concentrations of APOBEC3F and single-stranded DNA. Biochimica et Biophysica Acta (BBA) - General Subjects. 2020. 1864 (2).
5. Li Wan, Takashi Nagata, Masato Katahira. Influence of the DNA sequence/length and pH on deaminase activity, as well as the roles of the amino acid residues around the catalytic site of APOBEC3F. Physical Chemistry Chemical Physics. 2018. 20 (5), 3109-3117.
6. Li Wan, Takashi Nagata, Ryo Morishita, Akifumi Takaori-Kondo, and Masato Katahira. Observation by real-time NMR and interpretation of length- and location-dependency of deamination by APOBEC3B. ACS Chemical Biology. 2017. 12 (11), 2704-2708.
参与发表的论文：
1. Keisuke Kamba, Li Wan, Satoru Unzai, Ryo Morishita, Akifumi Takaori-Kondo, Takashi Nagata, Masato Katahira. Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway. Biophys J. 2024 Feb 6;123(3):294-306.
2. Stuti Sharma, Ruoyu Zhou, Li Wan, et al. Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins. Nature Communication. 2021.12, 4687. https: //doi.org /10.1038 /s41467-021-24965-1.
3. Yao Zhou, Diyin Li, Jianhua Luo, Aizhong Chen, Xingxing Li, Zhenrui Pan, Li Wan, Liuqing He, Danyang Li, Yanyan Li, Min Dong, Liang Tao. Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin. Cell Research. 2021.31, 935–938.
4. Ximin Chi, Qiongxuan Fan, Yuanyuan Zhang, Ke Liang, Li Wan, et al. Structural mechanism of phospholipids translocation by MlaFEDB complex. Cell Research. 2020. 30, 1127–1135.
5. Pengli Cai, Bang Wang, Jingxiao Ji, Yongsheng Jiang, Li Wan, Chaoguang Tian, and Yanhe Ma. The putative cellodextrin transporter-like protein CLP1 is involved in cellulase induction in Neurospora crassa. The Journal of Biological Chemistry. 2015, 290 (2), 788-96.
6. Dongdong Li, Yusheng Zheng, Li Wan, Xiaoming Zhu, Zhekui Zhang. Differentially expressed microRNAs during solid endosperm development in coconut (Cocos nucifera L.) Scientia Horticulturae.2009, 122(4):666-669.
目前，课题组处于初创阶段，欢迎对科研抱有热情的硕士研究生、博士研究生及博后的加盟。也欢迎本科生前来实验室学习体验。
