姓 名：林桓
职 称：副研究员
导师类别：博士生导师、硕士生导师
依托单位：海南大学南海海洋资源利用国家重点实验室
E-mail：linhuan@hainanu.edu.cn
一、个人基本情况
林桓，男，博士，副研究员，海南大学高层次引进人才。2019年3月加入海南大学。
曾先后在清华大学、东京大学、株式会社岛津制作所京都总部开展研究，主要从事RNA修饰及其生理功能挖掘以及生物质谱应用开发，并获得海南省C类高层次人才。以第一作者（含共同）、共通讯作者及合作者身份在Nature Communications、Nucleic Acids Research、Science bulletin等期刊发表研究论文多篇。获得国家自然科学基金青年项目，国家自然科学基金地区项目以及多项省部级项目资助。
二、研究方向
主要使用质谱，生物化学，结构生物学等方法对广泛模式/非模式生物的RNA修饰展开深入研究。研究方向包括：新型RNA修饰鉴定，RNA修饰功能挖掘，RNA修饰与环境响应，tRNA修饰完整图谱绘制等。
三、教育工作情况
2019-03至今，海南大学，副研究员，硕导/博导；
2017-04 至 2019-03，株式会社岛津制作所，GADC全球应用开发中心，副主任研究员；
2012-10 至 2017-03，东京大学，工学院研究科化学生命工程系，博士；
2009-09 至 2012-07，清华大学，生命科学学院，硕士；
2005-09 至 2009-07，清华大学，生物科学与技术系，学士。
四、荣誉奖励
1.海南省千人专项引才计划，2020
2.海南省领军人才，2020
五、代表性论文
First /co-first authors and Corresponding author published list (most recent first):
†Indicates co-first authors, * for Corresponding author.
1. Dehai Deng†, Yichao Qin†, Xiuying Lin, Meng Chu, Daizhu Lv, Huan Lin*. Unveiling transfer RNA modifications of oil palm and their dynamic changes during fruit ripening. BMC plant biology, 2025, 25:398.
2. Yan Wu, Li Ma, Zengheng Xiong, Danyu Huang, Mingshan Zhang, Xinrui Yang, Long Cheng, ShuhaiHe, Huan Lin*. Simultaneous determination of eight neonicotinoid insecticides and five metabolites in water samples by liquid chromatography-tandem mass spectrometry unveils an overlooked risk. Separation Science Plus, 2024, 7(7): e202400009.
3. Chen Yao, Daizhu Lv, Xueqing Zhou, Pengcheng Fu, Wen Sun, Jinlian Chen, Huan Lin*. Exploring urinary modified nucleosides as biomarkers for diabetic retinopathy: Development and validation of a ultra performance liquid chromatography-tandem mass spectrometry method. Journal of Chromatography B, 2024, 1232:123968.
4. Meng Chu, Yichao Qin, Xiuying Lin, Li Ma, Dehai Deng, Daizhu Lv, Pengcheng Fu, Huan Lin*. A preliminary survey of transfer RNA modifications and modifying enzymes of the tropical plant Cocos nucifera L. Genes, 2023, 14(6):1287.
5. Xiuying Lin, Qianhui Zhang, Yichao Qin, Qisheng Zhong, Daizhu Lv, Xiaopeng Wu, Pengcheng Fu, Huan Lin*. Potential misidentification of natural isomers and mass-analogs of modified nucleosides by liquid chromatography–triple quadrupole mass spectrometry. Genes, 2022, 13(5):878.
6. Yichao Qin, Qisheng Zhong, Ying Zhang, Xiuying Lin, Pengcheng Fu, Huan Lin*.Micro-flow hydrophilic interaction liquid chromatography coupled with triple quadrupole mass spectrometry detects modified nucleosides in the transfer RNA pool of cyanobacteria. Journal of Separation Science, 2021, 44(17):3208-3218
7. Huan Lin, Kenjyo Miyauchi, Tai Harada, Ryo Okita, Eri Takeshita, Hirofumi Komaki, Kaoru Fujioka, Hideki Yagasaki, Yu-ichi Goto, Kaori Yanaka, Shinichi Nakagawa, Yuriko Sakaguchi, Tsutomu Suzuki. CO2-sensitive tRNA modification associated with human mitochondrial disease. Nature Communications, 2018, 9: 1875.
Part of the participated works:
8. Meng-Han Huang, Jin-Tao Wang, Jian-Hui Zhang, Xue-Ling Mao, Gui-Xin Peng, Xiuying Lin, Daizhu Lv, Chen Yuan, Huan Lin, En-Duo Wang , Xiao-Long Zhou. Mitochondrial RNA m3C methyltransferase METTL8 relies on an isoform-specific N-terminal extension and modifies multiple heterogenous tRNAs. Science Bulletin, 2023, 68(18): 2094-2105.
9. Zengheng Xiong, Yan Wu, Yang Zhou, Shuhai He, Danyu Huang, Mingshan Zhang, Yanjun Jiang, Long Cheng, Zhendong Zhao, Hongwei Zhao, Huan Lin. Rapid determination and health risk assessment of neonicotinoids in source water and tap water of the tropical Hainan Island, China. Environmental Science and Pollution Research, 2023, online ahead of print.
10. Wen-Qing Yang, Qing-Ping Xiong, Jian-Yang Ge, Hao Li, Wen-Yu Zhu, Yan Nie, Xiuying Lin, Daizhu Lv, Jing Li, Huan Lin, Ru-Juan Liu. THUMPD3–TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates. Nucleic Acids Research, 2021, 49(20):11900-11919.
11. Takeo Suzuki, Yuka Yashiro, Ittoku Kikuchi, Yuma Ishigami, Hironori Saito, Ikuya Matsuzawa, Shunpei Okada, Mari Mito, Shintaro Iwasaki, Ding Ma, Xuewei Zhao, Kana Asano, Huan Lin, Yohei Kirino, Yuriko Sakaguchi & Tsutomu Suzuki. Complete chemical structures of human mitochondrial tRNAs. Nature Communications, 2020, 11(1):4269
