团队负责人：
柳志强，男，博士，教授，博士生导师，海南省拔尖人才，主讲微生物学、微生物学实验、基因工程实验等课程。目前主要从事病原真菌致病机制及防控，热带微生物资源开发与利用等相关研究，先后主持国家自然科学基金3项，海南省重点研发计划2项，海南省自然科学基金3项，参与国家科技支撑计划、国家自然科学基金、农业部农产品风险评估项目等多项，在国内外期刊发表学术论文50余篇，其中SCI论文20余篇。
团队介绍：
围绕危害动、植物及人类生命健康的重要病原真菌，系统研究病原真菌形态建成及致病相关基因的功能，深入解析其致病的分子机制，并针对病原真菌筛选有效的控制方法。本团队现有成员3人，其中教授2人，实验师1人，海南省“拔尖人才”2人。团队先后主持国家自然科学基金6项，海南省重点研发计划，高层次人才项目及海南省自然科学基金等多项，近5年发表SCI论文30余篇。
团队成员：李晓宇，唐雯
主要研究方向：
1. 病原真菌形态建成及调控机制
2. 病原真菌分子致病机制及防控技术
近五年主要研究成果：
[1] Yongqiang Yang, Xu Li, Zhenzhi Wang, Xiaoyan Huang, Duwen Zeng, Xinqing Zhao, Zhiqiang Liu*, Fengli Zhang*. Single cell protein production of co-culture Kodamaea ohmeri and Lactococcus lactis in corn straw hydrolysate. Bioresource Technology, 2025, 433: 132649.
[2] Yifan Gu, Xinyu Yang, Senhao Liu, Xiaowei Chen, Ran Liu, Jinglin Gao, Yihai Zhong, Xiaoyu Li*, Wensu Han*. RNAi-mediated knockdown of juvenile hormone acid methyltransferase depresses reproductive performance in female Aethina tumida. Pesticide Biochemistry and Physiology, 2025, 211: 106420.
[3] Shuangzhen Zhou, Chenchen Guo, Wen Tang, Zhiqiang Liu*, Xiaoyu Li*. Two homeobox transcription factors CgrHtf1 and CgrAfh1 hierarchically regulate asexual sporulation and appressorium formation in the maize anthracnose fungus Colletotrichum graminicola. Fungal Biology, 2025, 129: 101637.
[4] Yongqiang Yang, Xu Li, Zhifei Wang, Yulong Deng, Zhenzhi Wang, Xingyu Fang, Maodong Zhang, Wei Sun, Xinqing Zhao, Zhiqiang Liu*, Fengli Zhang*. Whole genome sequencing of Kodamaea ohmeri SSK and its characterization for degradation of inhibitors from lignocellulosic biomass. Biology, 2025, 14: 458.
[5] Shuangzhen Zhou, Shayu Liu, Chenchen Guo, Hanwen Wei, Zhihui He, Zhiqiang Liu*, Xiaoyu Li*. The C2H2 transcription factor Con7 regulates vegetative growth, cell wall integrity, oxidative stress, asexual sporulation, appressorium and hyphopodium formation, and pathogenicity in Colletotrichum graminicola and Colletotrichum siamense. Journal of Fungi, 2024, 10: 495.
[6] Jiujuan Zhao, Jinhua Sun, Min Li, Deqiang Gong, Jinyu Yang, Ying He, Zhiqiang Liu*, Meijiao Hu*. First report of anthracnose caused by Colletotrichum karstii on Dalbergia odorifera in China. Plant Disease, 2024, 108: 222.
[7] Jing Gao, Shuangzhen Zhou, Wen Tang, Jinhong Wang, Huanqing Liu, Ying Zhang, Liya Wang, Xiaoyu Li*, Zhiqiang Liu*. The velvet proteins CsVosA and CsVelB coordinate growth, cell wall integrity, sporulation, conidial viability and pathogenicity in the rubber anthracnose fungus Colletotrichum siamense. Microbiological Research, 2023, 268: 127290.
[8] Diguang Wang, Ying Zhang, Shuangzhen Zhou, Xingyuan Zhang, Shayu Liu, Xiaoyu Li*, Zhiqiang Liu*. Gcc1 homologs regulate growth, oxidative stress, conidiation and appressorium formation in Colletotrichum siamense and Colletotrichum graminicola. Microbial Pathogenesis, 2023, 182: 106249.
[9] Xiaoyu Li, Yanxia Zhao, Heungyun Moon, Jieyin Lim, Hee-Soo Park, Zhiqiang Liu*, Jae-Hyuk Yu*. The putative C2H2 transcription factor VadH governs development, osmotic stress response, and sterigmatocystin production in Aspergillus nidulans. Cells, 2022, 11, 3998.
[10] Jinhong Wang, Rui Wang, Jing Gao, Huanqing Liu, Wen Tang, Zhiqiang Liu, Xiaoyu Li*. Identification of three Streptomyces strains and their antifungal activity against the rubber anthracnose fungus Colletotrichum siamense. Journal of General Plant Pathology, 2023, 89: 67-76.
[11] Shumin Wang, Meijiao Hu, Xiangxiang Qu, Jinyu Yang, Zhaoyin Gao, Shuming Wang, Zhiqiang Liu*, Min Li*. First report of Colletotrichum queenslandicum causing leaf anthracnose on Dracaena cambodiana in China. Journal of General Plant Pathology, 2022, 88: 344-348.
[12] Xiaoyu Li, Zhijian Ke, Shuang Xu, Wen Tang , Zhiqiang Liu*. The G-protein alpha subunit CgGa1 mediates growth, sporulation, penetration and pathogenicity in Colletotrichum gloeosporioides. Microbial Pathogenesis, 2021, 161: 105254.
[13] Xiaoyu Li, Yateng Wu, Zhiqiang Liu*. Antifungal activity of an endophytic fungus Aspergillus versicolor DYSJ3 from Aphanamixis grandifolia Blume against Colletotrichum musae. Mycobiology, 2021, 49(5): 498-506.
[14] Xiaoyu Li, Shayu Liu, Nan Zhang, Zhiqiang Liu*. Function and transcriptome analysis of an oligopeptide transporter CgOPT2 in the rubber anthracnose fungus Colletotrichum gloeosporioides. Physiological and Molecular Plant Pathology, 2021, 115: 101661.
[15] Kai Zhang, Liushuang Gu, Yuefeng Zhang, Zhiqiang Liu*, Xiaoyu Li*. Dinactin from a new producer, Streptomyces badius gz-8, and its antifungal activity against the rubber anthracnose fungus Colletotrichum gloeosporioides. Microbiological Research, 2020, 240: 126548.
在研科研项目：
1. 李晓宇，橡胶树暹罗炭疽菌转录因子CsNrc1参与分生孢子发生的调控网络及分子机制研究，国家自然科学基金地区基金项目，2026/01-2029/12，32万元，项目编号：32560351
2. 柳志强，Homeobox型转录因子CgAfh1调控胶孢炭疽菌附着胞发育及侵染的分子机制，国家自然科学基金地区基金项目，2022/01-2025/12，34万元，项目编号：32160041
3. 李晓宇，橡胶炭疽病菌致病相关转录因子CgCon7的靶基因鉴定及调控机制，国家自然科学基金地区基金项目，2022/01-2025/12，35万元，项目编号：32160371
4. 柳志强， 橡胶炭疽病菌Velvet蛋白复合体CsVosA-CsVelB参与分生孢子发生与侵染的调控网络解析及新型药剂靶标筛选，海南省重点研发计划，2025/02-2028/02，72万元，项目编号：ZDYF2025XDNY072
5. 柳志强，Homeobox型转录因子CgrHtf1调控禾谷炭疽菌分生孢子发育及致病的分子机制，海南省自然科学基金高层次人才项目，2025/03-2028/02，10万元，项目编号：325RC641
6. 李晓宇，暹罗炭疽菌Velvet蛋白CsVeA调控分生孢子发生及侵染的分子机制，海南省自然科学基金高层次人才项目，2024/03-2026/02，10万元，项目编号：324RC449
代表性成果介绍：
1. 解析了暹罗炭疽菌Velvet蛋白CsVosA-CsVelB的调控功能及分子机制
2. 解析了构巢曲霉C2H2型转录因子VadH的生物学功能及调控机制
