一、个人基本情况
沈永义，理学博士，无党派人士，海南大学生命健康学院教授。国家优秀青年科学基金获得者。
二、教育工作经历
本科毕业于中国科学技术大学，2010年博士毕业于中科院昆明动物所，导师是张亚平院士。历任中科院昆明动物所遗传与进化国家重点实验室任副研究员，汕头大学医学院研究员。2013年-2014年，香港大学李嘉诚医学院，新发传染性疾病国家重点实验室，“香江学者计划”访问学者（合作导师：管轶教授）。2016-2026年，华南农业大学，兽医学院，动物疫病防控全国重点实验室研究员、博导；岭南现代农业科学与技术广东省实验室双聘PI。2026年至今，海南大学，生命健康学院，教授。
三、教学情况
讲授本科生的《分子生物学》、《兽医公共卫生》和《生物信息学导论》，研究生的《高级传染病学》、《兽医生物制品学》课程。
四、科研情况和科研项目
发表包含3篇Nature，1篇Science，4篇Nature子刊在内的SCI论文60余篇。
主持科研项目（课题）情况：
(1) 国家自然科学基金委员会，区域创新发展联合基金重点项目，华南地区重要病媒生物病毒谱、关键病毒的危害评估和生态阻断技术研究，U24A20363， 2025-2028，260万，主持
(2) 广东省科学技术厅，广东省重点领域研发计划“生物安全技术”重点专项，广东省野生动物病毒本底库构建、病毒风险评估及疫情预警，2022B1111040001，2022-2025，1000万元，主持
(3) 国家自然科学基金委员会，面上项目，异常偏好人唾液酸受体的H9N2禽流感病毒的演化机制研究，32273037，2023-2026，53万，主持
(4) 岭南现代农业科学与技术广东省实验室，双聘团队重大科技研究专项，新发/突发畜禽动物疫病的阻断技术研究，2021-2024，主持子课题（陈化兰院士为项目主持，分配255万）
(5) 广东省科技厅，广东省基础与应用基础研究重大项目，畜禽病原重要表型形成的分子机制，2020-2025，主持子课题（分配300万）
(6) 国家自然科学基金委员会，优秀青年基金项目，禽流感病毒进化生物学，31822056，2019-2021，130万元，主持
(7) 广东省科技厅，广东特支计划科技创新领军人才，2019TX05N098，80万元，主持
(8) 广东省科技厅，广东省防治新型冠状病毒科技攻关专项，新型冠状病毒动物溯源及人-动物循环的风险评估，2020B1111320002，2020-2021，80万元，主持
(9) 广东省自然科学基金委员会，杰出青年基金项目，华南地区主要野生动物携带病毒谱调查研究，2014A030306046，2015-2019，100万元，主持
(10) 国家自然科学基金委员会，面上项目，蝙蝠独特暗视觉系统的分子遗传机制研究，31172080，2012-2015，65万元，主持
五、研究领域
围绕“人病兽防，关口前移”的国家公共卫生防控战略，开展动物疫源疫病监测、病毒风险评估，以及高危害潜能病毒（禽流感和冠状病毒）跨种感染、拮抗宿主天然免疫分子机制研究。
六、社会兼职
国家林草局野生动物疫源疫病监控创新联盟、中国畜牧兽医学会公共卫生分会理事，多家野生动物繁育基地疫病指导专家，Frontiers in Microbiomes副主编以及Animal Diseases、Zoonotic Diseases、One Health、Microbes&Immunity等期刊编辑。
七、代表性成果
1. Dai, J., Qiu, X., Cui, X., Feng, Y., Hou, Y., Sun, Y., Liao, Y., Tan, L., Song, C., Liu, W., Shen, Y*., and Ding, C*., Newcastle disease virus infection remodels plasma phospholipid metabolism in chickens. iScience, 2024. 27(2): p. 108962.
2. Meng, Y., Irwin, D.M., and Shen, Y*., Ecology of SARS-CoV-2 in the post-pandemic era. Lancet Microbe, 2023. 4(4): p. e208.
3. Liang, X., Zhang, Z., Wang, H., Lu, X., Li, W., Lu, H., Roy, A., Shen, X., Irwin, D.M., and Shen, Y*., Early-life prophylactic antibiotic treatment disturbs the stability of the gut microbiota and increases susceptibility to H9N2 AIV in chicks. Microbiome, 2023. 11(1): p. 163.
4. Liang, X., Chen, X., Zhai, J., Li, X., Zhang, X., Zhang, Z., Zhang, P., Wang, X., Cui, X., Wang, H., Zhou, N., Chen, Z.J., Su, R., Zhou, F., Holmes, E.C., Irwin, D.M., Chen, R.A., He, Q., Wu, Y.J., Wang, C., Du, X.Q., Peng, S.M., Xie, W.J., Shan, F., Li, W.P., Dai, J.W., Shen, X., Feng, Y., Xiao, L., Chen, W*., and Shen, Y*., Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins. PLoS Pathog, 2023. 19(5): p. e1011384.
5. Huang, X.Y., Chen, Q., Sun, M.X., Zhou, H.Y., Ye, Q., Chen, W., Peng, J.Y., Qi, Y.N., Zhai, J.Q., Tian, Y., Liu, Z.X., Huang, Y.J., Deng, Y.Q., Li, X.F., Wu, A., Yang, X., Yang, G*., Shen, Y*., and Qin, C.F*., A pangolin-origin SARS-CoV-2-related coronavirus: infectivity, pathogenicity, and cross-protection by preexisting immunity. Cell Discov, 2023. 9(1): p. 59.
6. Cui, X., Fan, K., Liang, X., Gong, W., Chen, W., He, B., Chen, X., Wang, H., Wang, X., Zhang, P., Lu, X., Chen, R., Lin, K., Liu, J., Zhai, J., Liu, D.X., Shan, F., Li, Y., Chen, R.A., Meng, H., Li, X., Mi, S., Jiang, J., Zhou, N., Chen, Z., Zou, J.J., Ge, D., Yang, Q., He, K., Chen, T., Wu, Y.J., Lu, H., Irwin, D.M., Shen, X., Hu, Y., Lu, X., Ding, C*., Guan, Y*., Tu, C*., and Shen, Y*., Virus diversity, wildlife-domestic animal circulation and potential zoonotic viruses of small mammals, pangolins and zoo animals. Nat Commun, 2023. 14(1): p. 2488.
7. Xiao, K., Liang, X., Lu, H., Li, X., Zhang, Z., Lu, X., Wang, H., Meng, Y., Roy, A., Luo, W., Shen, X., Irwin, D.M., and Shen, Y*., Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats. Isme j, 2022. 16(8): p. 1980-1992.
8. Wang, R., Wang, X., Zhai, J., Zhang, P., Irwin, D.M., Shen, X., Chen, W*., and Shen, Y*., A new canine distemper virus lineage identified from red pandas in China. Transbound Emerg Dis, 2022. 69(4): p. e944-e952.
9. Li, X., Bi, R., Xiao, K., Roy, A., Zhang, Z., Chen, X., Peng, J., Wang, R., Yang, R., Shen, X., Irwin, D.M., and Shen, Y*., Hen raising helps chicks establish gut microbiota in their early life and improve microbiota stability after H9N2 challenge. Microbiome, 2022. 10(1): p. 14.
10. Yang, R., Peng, J., Zhai, J., Xiao, K., Zhang, X., Li, X., Chen, X., Chen, Z.J., Holmes, E.C., Irwin, D.M., Shan, F., Shen, X., Chen, W*., and Shen, Y*., Pathogenicity and transmissibility of a novel respirovirus isolated from a Malayan pangolin. J Gen Virol, 2021. 102(4).
11. Xiao, K., Fan, Y., Zhang, Z., Shen, X., Li, X., Liang, X., Bi, R., Wu, Y., Zhai, J., Dai, J., Irwin, D.M., Chen, W*., and Shen, Y*., Covariation of the Fecal Microbiome with Diet in Nonpasserine Birds. mSphere, 2021. 6(3).
12. Guo, F., Roy, A., Wang, R., Yang, J., Zhang, Z., Luo, W., Shen, X., Chen, R.A., Irwin, D.M., and Shen, Y*., Host Adaptive Evolution of Avian-Origin H3N2 Canine Influenza Virus. Front Microbiol, 2021. 12: p. 655228.
13. Xiao, K., Zhai, J., Feng, Y., Zhou, N., Zhang, X., Zou, J.J., Li, N., Guo, Y., Li, X., Shen, X., Zhang, Z., Shu, F., Huang, W., Li, Y., Zhang, Z., Chen, R.A., Wu, Y.J., Peng, S.M., Huang, M., Xie, W.J., Cai, Q.H., Hou, F.H., Chen, W*., Xiao, L*., and Shen, Y*., Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins. Nature, 2020. 583(7815): p. 286-289.
14. Guo, F., Yang, J., Pan, J., Liang, X., Shen, X., Irwin, D.M., Chen, R.A., and Shen, Y*., Origin and Evolution of H1N1/pdm2009: A Codon Usage Perspective. Front Microbiol, 2020. 11: p. 1615.
15. Shen, X., Sabir, J.S.M., Irwin, D.M., and Shen, Y*., Vaccine against Middle East respiratory syndrome coronavirus. Lancet Infect Dis, 2019. 19(10): p. 1053-1054.
16. Pu, Z., Luo, T., Yang, J., Shen, X., Irwin, D.M., Liao, M., and Shen, Y*., Rapid evolving H7N9 avian influenza A viruses pose new challenge. J Infect, 2019. 78(3): p. 249-259.
17. Guo, F., Li, Y., Yu, S., Liu, L., Luo, T., Pu, Z., Xiang, D., Shen, X., Irwin, D.M., Liao, M., and Shen, Y*., Adaptive Evolution of Human-Isolated H5Nx Avian Influenza A Viruses. Front Microbiol, 2019. 10: p. 1328.
18. Zhang, X., Luo, T., and Shen, Y*., Deciphering the Sharp Decrease in H7N9 Human Infections. Trends Microbiol, 2018. 26(12): p. 971-973.
19. Xiang, D., Shen, X., Pu, Z., Irwin, D.M., Liao, M., and Shen, Y*., Convergent Evolution of Human-Isolated H7N9 Avian Influenza A Viruses. J Infect Dis, 2018. 217(11): p. 1699-1707.
20. Xiang, D., Irwin, D.M., and Shen, Y*., The H7N9 viruses have lost most of their previous lineages in the fifth wave. J Infect, 2018. 76(4): p. 417-418.
21. Pu, Z., Xiang, D., Li, X., Luo, T., Shen, X., Murphy, R.W., Liao, M., and Shen, Y*., Potential Pandemic of H7N9 Avian Influenza A Virus in Human. Front Cell Infect Microbiol, 2018. 8: p. 414.
22. Shen, Y., Ke, C.W., Li, Q., Yuan, R.Y., Xiang, D., Jia, W.X., Yu, Y.D., Liu, L., Huang, C., Qi, W.B., Sikkema, R., Wu, J., Koopmans, M., and Liao, M., Novel Reassortant Avian Influenza A(H5N6) Viruses in Humans, Guangdong, China, 2015. Emerg Infect Dis, 2016. 22(8): p. 1507-9.
23. Sabir, J.S#., Lam, T.T#., Ahmed, M.M#., Li, L#., Shen, Y., Abo-Aba, S.E., Qureshi, M.I., Abu-Zeid, M., Zhang, Y., Khiyami, M.A., Alharbi, N.S., Hajrah, N.H., Sabir, M.J., Mutwakil, M.H., Kabli, S.A., Alsulaimany, F.A., Obaid, A.Y., Zhou, B., Smith, D.K., Holmes, E.C., Zhu, H., and Guan, Y., Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia. Science, 2016. 351(6268): p. 81-4.
24. Lam, T.T#., Zhou, B#., Wang, J#., Chai, Y#., Shen, Y#., Chen, X#., Ma, C., Hong, W., Chen, Y., Zhang, Y., Duan, L., Chen, P., Jiang, J., Zhang, Y., Li, L., Poon, L.L., Webby, R.J., Smith, D.K., Leung, G.M., Peiris, J.S., Holmes, E.C., Guan, Y., and Zhu, H., Dissemination, divergence and establishment of H7N9 influenza viruses in China. Nature, 2015. 522(7554): p. 102-5.
25. Lam, T.T#., Wang, J#., Shen, Y#., Zhou, B., Duan, L., Cheung, C.L., Ma, C., Lycett, S.J., Leung, C.Y., Chen, X., Li, L., Hong, W., Chai, Y., Zhou, L., Liang, H., Ou, Z., Liu, Y., Farooqui, A., Kelvin, D.J., Poon, L.L., Smith, D.K., Pybus, O.G., Leung, G.M., Shu, Y., Webster, R.G., Webby, R.J., Peiris, J.S., Rambaut, A., Zhu, H., and Guan, Y., The genesis and source of the H7N9 influenza viruses causing human infections in China. Nature, 2013. 502(7470): p. 241-4.
26. Ge, R.L#., Cai, Q#., Shen, Y#., San, A., Ma, L., Zhang, Y., Yi, X., Chen, Y., Yang, L., Huang, Y., He, R., Hui, Y., Hao, M., Li, Y., Wang, B., Ou, X., Xu, J., Zhang, Y., Wu, K., Geng, C., Zhou, W., Zhou, T., Irwin, D.M., Yang, Y., Ying, L., Bao, H., Kim, J., Larkin, D.M., Ma, J., Lewin, H.A., Xing, J., Platt, R.N., 2nd, Ray, D.A., Auvil, L., Capitanu, B., Zhang, X., Zhang, G., Murphy, R.W., Wang, J., Zhang, Y.P., and Wang, J., Draft genome sequence of the Tibetan antelope. Nat Commun, 2013. 4: p. 1858.
27. Shen, Y., Liang, L., Li, G.S., Murphy, R.W., and Zhang, Y.P., Parallel evolution of auditory genes for echolocation in bats and toothed whales. PLoS Genet, 2012. 8(6): p. e1002788.
28. Sun, Y.B#., Shen, Y#., Irwin, D.M., and Zhang, Y.P., Evaluating the roles of energetic functional constraints on teleost mitochondrial-encoded protein evolution. Mol Biol Evol, 2011. 28(1): p. 39-44.
29. Shen, Y., Liang, L., Zhu, Z.H., Zhou, W.P., Irwin, D.M., and Zhang, Y.P., Adaptive evolution of energy metabolism genes and the origin of flight in bats. Proc Natl Acad Sci U S A, 2010. 107(19): p. 8666-71.
30. Shen, Y., Shi, P., Sun, Y.B., and Zhang, Y.P., Relaxation of selective constraints on avian mitochondrial DNA following the degeneration of flight ability. Genome Res, 2009. 19(10): p. 1760-5.
八、荣誉奖励
1. 2019年广东省科技进步一等奖，禽流感预警和防控关键技术创新与应用，排名2/15
2. 2019年广东特支计划科技创新领军人才
3. 2019年国家自然科学基金优秀青年基金获得者
4. 2018年科技部重点领域创新团队
5. 2016年广东特支计划百千万工程青年拔尖人才
6. 2014年广东省杰出青年基金获得者
7.2013年云南省自然科学一等奖，动物适应性进化的分子机制，排名3/5
8. 2011年中国科学院百篇优秀博士生论文
