一、个人基本情况

王灵，博士，中共党员，生物学科研流动站博士后，合作导师：林坚。E-mail：wl0929@hainanu.edu.cn

二、教育工作经历

2014.9-2018.6，华中农业大学，水族科学与技术，农学学士

2018.9-2021.6，中国科学院大学南海海洋研究所，生物工程，工学硕士

2021.8-2025.6，澳门大学，生物医药，获博士学位

2025.9-至今，海南大学，全职博士后

三、主要研究领域

  药物开发与靶向递送，药理学研究，工程化外泌体在脑部疾病的应用。

四、科研情况

代表性论文

(1) Wang L^#, Kong LT^#, Zhang DQ^#, Chan D, Li XY, Peng YT, Yang LJ, Wong CY, Wong VKW,* Wang WH,* Chao H* and Leung CH*.(2025) Inhibiting glycolysis and disrupting the mitochondrial HK2-VDAC1 protein-protein interaction using a bifunctional lonidamine-conjugated metal probe for combating triple-negative breast cancer. J. Am. Chem. Soc. 147(17), 14824-14836. (共同第一作者)

(2) Wang L^#, Wang XL^#, Chen F, Song YQ, Nao SC, Chan D, Wong CY, Wang WH* and Leung CH*. (2024) A glycyrrhetinic acid-iridium(III) conjugate as a theranostic NIR probe for hepatocellular carcinoma with mitochondrial-targeting ability. Eur. J. Med. Chem. 264, 115995. (共同第一作者)

(3) Wang L^#, Liu JQ^#, Chen F^#, Li GD, Wang J, Chan D, Wong CY, Wang WH* and Leung CH*. (2023)A switch-on affinity-based iridium(III) conjugate probe for imaging mitochondrial glutathione S-transferase in breast cancer cells. Bioconjugate Chem. 34, 1727-1737. (共同第一作者)

(4) Kong LT^#, Wang L^#, Zhang ZX^#, Ye LQ, Chan SH, Wong CY*, Wang J*, Leung CH* and Wang WH*.(2025) Probing Mitochondrial Peroxynitrite Biogenesis by a N-Morpholinoarylimine-Based Iridium(III) Complex in Drug-Induced Liver Cells. Redox Biol.103805. (共同第一作者)

(5) Du JX^#, Wang L^#, Wu L, Liu JB*, Leung CH*, Wang WH*. (2025) A subcellular specific iridium complex boosting cuproptosis for cancer theranostics. Cell Rep. Phys. Sci. 6(5), 102592. (封面，共同第一作者)

(6) Kong LT^#, Wang L^#, Jing SZ, Wang J*, Leung CH (Corresponding author)* and Wang WH*.(2025) A Novel N-Alkyhydrazone-based Iridium(III) Complex for Luminescence Imaging of Mitochondrial Hypochlorous Acid in Liver Injury. Anal Chim Acta. 1368, 344327. (共同第一作者)

(7) Xu YW^#, Wang L^#, Du JX^#, Chan D, Wu L, Jia MZ, Liu JB, Wong YC, Yang K*, Leung CH*, Wang WH,*(2025) A Bivalent Iridium(III) Complex Toolkit for Mitochondrial DNA G-Quadruplex-Targeted Theranostics. Chem. Eur. J. 31(23), e202403853. (共同第一作者)

(8) Song YQ^#, Xu YW^#, Yang LJ^#, Wang L^#, Jing SZ, Yang GJ, Chan D, Wong CY, Wang WH*, Wong VKW* and Leung CH*.(2024) Probing the AFF4-CCNT1 protein-protein interaction using a metal-organic conjugate for treating triple-negative breast cancer. Chem Eng J 496, 153685. (共同第一作者)

(9) Cheng SS, Li J, Song YQ, Jing SZ, Lan YX, Wang L, Chan D, Wong CY, Sheng CQ*, Wang WH*, Wang HM*, Leung CH*.(2025) Bioactive Benzimidazole-cyclometalated Iridium(III) Complex as an Epigenetic Regulator through Effectively Interrupting the EED-EZH2 Interaction. Small 21(12). (参与)

(10) Jing SZ, Song YQ, Liu JQ, Zhao C, Wang L, Chan D, Wong CY, Lee SMY, Wang J*, Leung CH* and Wang WH*.(2024) A NIR iridium(III) complex-based luminescence probe for imaging mitochondria pyruvate dehydrogenase kinase 1 in triple-negative breast cancer cells. Sensor Actuat B-Chem 418, 136265. (参与)

(11) Chen F, Li GD, Wu C, Wang L, Ko CN, Ma DL* and Leung CH*. (2022) An interference reduction biosensing strategy for highly sensitive microRNA detection. Anal Chem 94, 10, 4513–452. (参与)

(12) Wang WH*, Liu JH, Kong LT, Wang L, Niu D, Wang J*, and Leung CH*. (2023) Synthesis and luminescence monitoring of iridium(III) complex-functionalized gold nanoparticles and their application for determination of gold(III) ions. Microchim Acta 190, 171. (参与)