姓 名：敖英
职 称：教授（高聘）
E-mail：aoyingszu@163.com
一、个人基本情况
敖英，博士，教授（高聘）
2014年获得中山大学博士学位，2014-2019武汉大学-深圳大学联合培养博士后，2019-2024深圳大学副研究员，2025-至今海南大学生命健康学院。获国家自然科学基金青年基金，国家自然科学基金面上基金，深圳市基础项目等科研基金的资助。
二、教育经历
(1) 2009-09 至 2014-07, 中山大学, 遗传学, 理学博士
(2) 2005-09 至 2009-07, 四川农业大学, 生物医学工程, 理学学士
三、研究方向
衰老机制与抗衰老干预策略研究，聚焦于免疫衰老的调控机制，探索衰老与肿瘤免疫间的相互作用，小分子药物干预衰老策略研究。
四、科研项目
(1) 国家自然科学基金委员会, 面上项目, 82071580, 蛋白激酶CK2负调控cGAS-STING通路对机体衰老的作用机制研究 , 2021-01-01 至 2024-12-31, 56万元, 主持
(2) 国家自然科学基金青年科学基金项目，31501109，A型核纤层蛋白C-末端磷酸化调控细胞衰老及其通路的研究，2016.01-2018.12，21万元，主持
(3) 深圳市科技创新委员会高校稳定支持计划研究项目，JCYJ20200814152850001，蛋白激酶CK2调控cGAS-STING通路对机体衰老的作用机制研究，2019.08-2022.12，30万元，主持
五、代表性论著（# 第一作者, * 通讯作者）
(1) Jie Zhang, Pengfei Sun, Zhuping Wu, Jie Wu, Jiali Jia, Haoman Zou, Yanzhen Mo, Zhongjun Zhou, Baohua Liu, Ying Ao*, Zimei Wang*; Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24-deficient mice., Cell Death & Disease, 2024, 15:380中科院JCR 1 区，IF: 8.1
(2) Ying Ao #; Jie Zhang #; Zuojun Liu; Minxian Qian; Yao Li; Zhuping Wu; Pengfei Sun; Jie Wu
; Weixin Bei; Junqu Wen; Xuli Wu; Feng Li; Zhongjun Zhou; Wei-Guo Zhu; Baohua Liu; Zimei Wang ; Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model., Science Advances, 2019, 5(3) 中科院JCR 1 区，IF: 13.117
(3) Jie Zhang #; Ying Ao #; Zhen Zhang; Yanzhen Mo; Linyuan Peng; Yue Jiang; Zimei Wang; Baohua Liu ; Lamin A safeguards the m6A methylase METTL14 nuclear speckle reservoir to prevent cellular senescence, Aging cell, 2020, 19(10) 中科院JCR 1 区，IF: 9.304
(4) Ying Ao*†, Zhuping Wu†, Zhiwei Liao, Juncong Lan, Jie Zhang, Pengfei Sun, Baohua Liu, Zimei Wang* ; Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence., Cells, 2023, 12, 639. 中科院JCR 2 区，IF: 6.0
(5) Ao, Ying #; Li, Zhangqun #; Feng, Dongru #; Xiong, Feng; Liu, Jun; Li, Jian-Feng; Wang, M
englong; Wang, Jinfa; Liu, Bing; Wang, Hong-Bin ; OsCERK1 and OsRLCK176 play important roles in peptidoglycan and chitin signaling in rice innate immunity., Plant Journal, 2014, 80(6): 1072-1084中科院JCR 2 区，IF: 5.972
(6) Liu, Bing #; Li, Jian-Feng #; Ao, Ying #; Qu, Jinwang; Li, Zhangqun; Su, Jianbin; Zhang,
Yang; Liu, Jun; Feng, Dongru; Qi, Kangbiao; He, Yanming; Wang, Jinfa; Wang, Hong-Bin ; Lysin motif-containing proteins LYP4 and LYP6 play dual roles in peptidoglycan and chitin perception in rice innate immunity., Plant Cell, 2012, 24(8): 3406-3419中科院JCR 1 区，IF: 9.251
(7) Zhangqun Li #; Ying Ao #; Dongru Feng; Jun Liu; Jinfa Wang; Hong-Bin Wang; Bing Liu ; OsRLCK57, OsRLCK107 and OsRLCK118 Positively Regulate Chitin- and PGN Induced Immunity in Rice, RICE, 2017, 10(6) 中科院JCR 1 区，IF: 3.039
(8) Liu, Bing #; Li, Jian-Feng #; Ao, Ying #; Li, Zhangqun; Liu, Jun; Feng, Dongru; Qi, Kangbiao; He, Yanming; Zeng, Liexian; Wang, Jinfa; Wang, Hong-Bin ; OsLYP4 and OsLYP6 play critical roles in rice defense signal transduction, Plant Signal Behav, 2013, 8(2) (期刊论文)
(9) Wang, Ming; Wang, Lulu; Qian, Minxian; Tang, Xiaolong; Liu, Zuojun; Lai, Yiwei; Ao, Ying; Huang, Yinghua; Meng, Yuan; Shi, Lei; Peng, Linyuan; Cao, Xinyue; Wang, Zimei; Qin, Baoming; Liu, Baohua; PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome., Aging Cell, 2020, 19(6). (期刊论文)
(10) Qian, Minxian; Liu, Zuojun; Peng, Linyuan; Tang, Xiaolong; Meng, Fanbiao; Ao, Ying; Zhou, Mingyan; Wang, Ming; Cao, Xinyue; Qin, Baoming; Wang, Zimei; Zhou, Zhongjun; Wang, Guanming; Gao, Zhengliang; Xu, Jun; Liu, Baohua ; Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria., eLife, 2018, 7: 0-e34836. (期刊论文)
