一、个人基本情况

胡艳霞，医学博士，海南大学高层次引进人才，“环境应激与健康稳态”团队骨干。

二、教育情况

2012-2017就读于重庆医科大学医学检验（五年制）专业，获医学学士学位

2017-2020就读于重庆医科大学临床检验诊断学专业，获医学硕士学位

2020-2023就读于中山大学基础医学专业，获医学博士学位

自2024年3月在海南大学工作。

三、教学情况

讲授本科生《细胞生物学》、《环境分子生物学》和研究生《环境毒理与健康风险》等课程。获得2025年海南大学“AI赋能”课堂教学展示大赛三等奖。

三、科研情况

主要关注RNA修饰及其调控因子在环境应激响应与肿瘤发生发展中的功能作用和分子机制。已发表SCI论文20余篇，代表性成果以第一作者（含共同）身份发表在Hepatology，Advanced Science和Nature Communications 等领域重要期刊上。发表于Hepatology的工作获得编辑配发的Editorial 评论。

四、科研项目

海南省自然科学基金，2025-2027，主持。

五、社会兼职

海南省免疫学会青年工作委员会，委员、秘书

六、代表性论文

1）Yanxia Hu^#, Liting Diao^#, Yarui Hou^#, Guo Lv, Shuang Tao, Wanyi Xu, Shujuan Xie, Yahan Ren, and Zhendong Xiao*. Pseudouridine synthase 1 promotes hepatocellular carcinoma through mRNA pseudouridylation to enhance the translation of oncogenic mRNAs. Hepatology, 2024, 80(5): 1058-1073. (Editorial评论文章)

2）Yarui Hou^#, Liting Diao^#, Yanxia Hu^#, Qianqian Zhang, Guo Lv, Shuang Tao, Wanyi Xu, Shujuan Xie*, Qi Zhang*, and Zhendong Xiao*. The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO-Mediated Nuclear Export of ZEB1 mRNA. Advanced Science, 10(23): e2301983.

3）Yajun Xie^#, Xiaoyan Lv^#, Dongsheng Ni^#, Jianing Liu^#, Yanxia Hu^#, Yamin Liu^#, Yunhong Liu, Rui Liu, Hui Zhao and Zhimin Lu*, Qin Zhou*. HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage. Nature Communications, 2019; 10(1): 4266.

4）Faming Zhao^#, Tingting Zhang^#, Jinlan Wei, Liang Chen, Zaoqu Liu, Yang Jin, Mingsheng Liu, Hongqing Zhou, Yanxia Hu, and Xia Sheng*. (2024). Integrated single-cell transcriptomic analyses identify a novel lineage plasticity-related cancer cell type involved in prostate cancer progression. EBioMedicine, 2024, 109: e105398.

5）Liting Diao, Shujuan Xie, Wanyi Xu, Haihui Zhang, Yarui Hou, Yanxia Hu, Xinxiang Liang, Junbin Liang, Qi Zhang*, and Zhendong Xiao*. CRISPR/Cas13 sgRNA-Mediated RNA-RNA Interaction Mapping in Live Cells with APOBEC RNA Editing. Advanced Science, 2024, 11(45): e2409004.

6）Tingting Zhang^#, Faming Zhao^#, Yanxia Hu, Jinlan Wei, Fengzhen Cui, Yahang Lin, Yang Jin, Xia Sheng*. Environmental monobutyl phthalate exposure promotes liver cancer via reprogrammed cholesterol metabolism and activation of the IRE1alpha-XBP1s pathway. Oncogene, 2024, 43(30): 2355-2370.

7）Shuang Tao^#, Shujuan Xie^#, Liting Diao^#, Guo Lv, Yarui Hou, Yanxia Hu, Wanyi Xu, Bin Du*, and Zhendong Xiao*. RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization. Journal of experimental & clinical cancer research, 2023, 42(1): 194.