一、个人基本情况

孙昊，理学博士，中共党员，海南大学生命健康学院副研究员。

二、教育工作经历

2011.08-2015.06 东北农业大学，生命科学学院，生物科学（理科实验班），本科

2015.09-2020.12 南开大学，生命科学学院，微生物学，直博

2021.01-2026.06 南开大学，泰达生物技术研究院，博士后，助理研究员

2026年至今 海南大学，生命健康学院，副研究员

三、科研情况

围绕病原菌-宿主相互作用的科学问题，致力于病原细菌致病机制的系统研究，尤其以新生儿脑膜炎大肠杆菌和阪崎克罗诺杆菌为模型，揭示病原菌在宿主体内感知微环境信号、调控毒力基因表达、穿越血脑屏障及逃逸免疫清除的分子策略。

主要研究方向：病原菌穿越血脑屏障的分子机制；sRNA及转录调控网络介导的毒力调控；病原菌代谢适应与宿主免疫逃逸。

代表性成果以第一或通讯作者（含共同）身份发表在Nature Communications，Cell Reports，PNAS，Virulence，Food Research International等主流期刊。

四、科研项目

1. 国家自然科学基金青年科学基金项目C类，30万，2025.01-2027.12，在研，主持

2. 海南大学科研启动项目，2026.06-2031.06，50万，在研，主持

3. 传染病溯源预警与智能决策全国重点实验室青年基金项目，2024.01-2024.12，10万，结题，主持

4. 国家自然科学基金国际(地区)合作与交流项目 NSFC-RSF(中俄)，2026.01-2028.12，150万，在研，参与

5. 国家自然科学基金面上项目，2023.01-2026.12，54万，在研，参与

五、代表性成果（论文、专利、专著等）

1. Hao Sun#, Xiaoya Li#, Xinyuan Yang, Jingliang Qin, Yutao Liu, Yangyang Zheng, Qian Wang, Ruiying Liu, Hongmin Sun,Xintong Chen, QiyueZhang, Tianyuan Jia, Xiaoxue Wu, LuFeng, Lei Wang*, Bin Liu*, Low leucine levels in the blood enhance the pathogenicity of neonatal meningitis-causing Escherichia coli. Nat Commun. 2025 Mar 12;16(1):2466.

2. Hao Sun#, Xuehua Wan#, Yu Fan#, Peng Liu#, Yajun Song, Ningyu Zhu, Zhifeng Duan, Qian Wang, Fang Chen, Changhong Zhou, Yangyang Zheng, Peng Ding, Fenxia Liu, Lu Feng, KwangSik Kim, Lei Wang*, L. Bacteria reduce flagellin synthesis to evade microglia-astrocyte-driven immunity in the brain. Cell Rep. 2022 Jul 5;40(1):111033.

3. Xiaoya Li#, Hao Sun#, Xinyuan Yang, Liying Feng, Yuanyuan Niua, Binbin Xiang, Jingliang Qin, Jiake Wang, Zhengang Li, Lu Wang, Lu Feng, Lei Wang* and Bin Liu*, sRNA centered signaling activates nitrate respiration and enhances Cronobacter sakazakii virulence in host environments. Nat Commun. 2026 Mar 3;17(1):3373.

4. Xiaoya Li#, Di Huang#, Ruiying Liu#, Qiyue Zhang, Xinyuan Yang, Jiake Wang, Min Wang, Qian Wang, Jianwei Mu, Xintong Chen, Miaomiao Liu, Sijia Liu, Hao Sun*, Bin Liu*, The reactive oxygen species-induced small RNA CsrO promotes the survival of Cronobacter sakazakii in macrophages and systemic infection within the host. Food Res Int. 2025 Dec;221(Pt 4):117545.

5. Bin Liu#, Yingying Su#, Hao Sun#, BinYang#, Lili Wan,Xiaoya Li, ShaobinHou, Guozhen Ma, Juan Joanna Yu, LuFeng*, Huamin Henry Li*, LeWang* Vamp3/syntaxin 4 mediates the basolateral membrane fusion of TfR transcytosis across the BBB and is exploited by pathogenic E. coli. Proc Natl Acad Sci U S A. 2025 Jul 8;122(27):e2500285122.

6. Hao Sun, Yajun Song, FangChen, Changhong Zhou, PengLiu, YuFan, Yangyang Zheng, Xuehua Wan, LuFeng* An ArcA-Modulated Small RNA in Pathogenic Escherichia coli K1. Front Microbiol. 2020 Nov 23;11:574833.

7. Qian Wang#, Yi Wei#, Yu Huang, Jingliang Qin, Bin Liu, Ruiying Liu, Xintong Chen, Dan Li, Qiushi Wang, Xiaoya Li, Xinyuan Yang, Yuanke Li*, Hao Sun*, Z3495, a LysR-Type Transcriptional Regulator Encoded in O Island 97, Regulates Virulence Gene Expression in Enterohemorrhagic Escherichia coli O157:H7. Microorganisms. 2024 Jan 10;12(1):140.

8. Yangyang Zheng#, Hao Sun#, Yanling Wang, Chen Jin, Xiaoya Li, Yu Pang, Qianwen Ge, Lei Wang, Bin Liu* CsiR-Mediated Signal Transduction Pathway in Response to Low Iron Conditions Promotes Escherichia coli K1 Invasion and Penetration of the Blood-Brain Barrier. J Infect Dis. 2024 Oct 16;230(4):e807-e817.

9. Ting Yao, Yu Huang, Zimeng Huai, Xingmei Liu, Xiaowen Liu, Yutao Liu, Hao Sun*, Yu Pang*, Response mechanisms to acid stress promote LF82 replication in macrophages. Front Cell Infect Microbiol. 2023 Oct 10;13:1255083. doi: 10.3389/fcimb.2023.1255083.

10. Yingying Su, Guozhen Ma, Yangyang Zheng, Jingliang Qin, Xiaoya Li, Qianwen Ge, Hao Sun*, Bin Liu*, Neonatal Meningitis-Causing Escherichia coli Induces Microglia Activation which Acts as a Double-Edged Sword in Bacterial Meningitis. Int J Mol Sci. 2023 Jun 8;24(12):9915.