一、个人基本情况

   郑继平 三级教授，海南省一流本科课程《微生物生物学》（线上）、《微生物学A》（线下）、对外开放精品课程《病毒学》课程负责人，海南省生物与医药教学委员会委员，海南省免疫学会常务理事，《生物技术通迅》和《热带生物学报》编委，曾于1999获军队科学技术进步二等奖1项（排名3），于2019年入选海南省“领军人才”和首批“南海名家”。

二、教育工作情况

  2004年 博士毕业于军事科学院（军事医学科学院）

  1998年 硕士毕业于吉林大学（解放军农牧大学）

  1995年 本科毕业于河南大学

三、教学情况

  主讲本科生《微生物学》和《病毒学》课程。

四、科研情况

  主要从事微生物遗传、病原微生物感染与免疫等方面研究。研究领域主要集中在：（1）传染病诊断、病原检测和监测；（2）人与动物病原的跨种间传播机制；（3）病原耐药性形成、传播与迁移机制；（4）病原的干预防控新策略。当前研究内容是致病性气单胞菌的耐药形成与传播机制、致病性气单胞菌的致病机制与干预防控新策略。

五、代表性科研项目

   1) 2026-03-2029-03海南省重点研发项目（ZDYF2026SHFZ045）：热带致病性气单胞菌耐药机制与干预控制新策略，299万元.

   2) 2024-02-2027-02，海南省重点研发项目（ZDYF2024SHFZ142）：基于多基因无痕敲除的达卡气单胞菌弱毒疫苗研制与评价，76万.

   3) 2021-01-2024-12 国家自然科学基金 地区项目（32060131）：鳄鱼源达卡气单胞菌PhoBR的毒力调控机制，35万.

   4) 2017-01-2019-12 海南自然科学基金创新研究团队项目（2017CXTD005）：无乳链球菌磷调节子研究. 30万.

六、近五年论文

[1] Li X, Wang M, Di Z, Xu Y, Wu Y, Ye S, Yi A, Guo G, Fan L, Yang N et al: Comparative assessment of ΔarnA and ΔugdΔarnA mutants of Aeromonas dhakensis as live attenuated vaccine candidates: implications for polymyxin resistance and virulence attenuation. Microbial pathogenesis 2026: 108331.

[2] Wang X, Yang C, Liu H, Zhao J, Feng W, Wu Y, Ye S, Guo G, Fan L, Yang N et al: Deletion of wecA attenuates Aeromonas dhakensis and elicits protection in a zebrafish model: implications for transboundary aquaculture biosecurity. Fish & shellfish immunology 2026, 169:111045.

[3] Feng W, Huang S, Yi A, Wang X, Wu Y, Li X, Yang N, Fan L, Guo G, Zheng J: The quadruple gene mutant (aerA-ahh1-rtxA-th) of Aeromonas dhakensis shows reduced virulence and promising vaccine development potential. Fish & Shellfish Immunology 2026, 168: 110952.

[4] Li X, Wang M, Chen L, Gao H, Lin Y, Wu Y, Ye S, Yi A, Guo G, Fan L et al: Dual deletion of ugd and phoB attenuates virulence and enhances vaccine potential in Aeromonas dhakensis. BMC Veterinary Research 2026, 22(1): 4.

[5] Guo G, Di Z, Huang S, Li X, Yang N, Fan L, Xie J, Cai X, Meng Y, Yan F et al: Virulence and resistance adaptation of Streptococcus agalactiae Ib/ST261 infecting bullfrogs in Hainan, China between 2019 and 2023. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 2026, 57(1): 82.

[6] Wang X, Yang C, Li X, Feng W, Zhao J, Wu Y, Ye S, Zhao M, Li H, Ju J et al: Targeting argH to attenuate Aeromonas dhakensis virulence: a metabolic checkpoint for biofilm formation and stress adaptation. Veterinary Microbiology 2025, 311: 110767.

[7] Zhang B, Ye S, Duan X, Gao H, Wu Y, Chen D, Yu J, Wang X, Feng W, Guo G et al: Antagonistic activity of Bacillus velezensis L09 isolated from crocodile gut against Aeromonas dhakensis: mechanisms and potential for aquaculture applications. Water Biology and Security 2025: 100528.

[8] Feng W, Li X, Yang N, Fan L, Guo G, Xie J, Cai X, Meng Y, Zeng J, Han Y et al: The PhoBR two-component system upregulates virulence in Aeromonas dhakensis C4–1. Aquaculture 2024: 741665.

[9] Wang P, Shao Y, Yang X, Zhang W, Zhou J, Huang F, Liu S, Zheng J, Wu C, Li S: Construction of a bivalent vaccine candidate against HAdV4/HAdV7 based on capsid-display strategy via Red-homologous recombination and counter-selection methodology. Biosafety and Health 2024, 6(2): 70-79.

[10] Wang M, Li X, Guo G, Rehman MNU, Gao X, Fan L, Yang N, Zeng J, Zheng J: Emergence of highly virulent and multidrug-resistant Escherichia coli in breeding sheep with pneumonia, Hainan Province, China. Frontiers in Microbiology 2024, 15: 1479759.

[11] Fan L, Pan J, Zeng J, Guo G, Yang N, Li X, Nafees Ur Rehman M, Zheng J: An outbreak of Providencia rettgeri bacteremia at a Ptyas mucosus farm in Hainan, China. Frontiers in Microbiology 2024, 15: 1353603.

[12] Chen L, Wang Y, Fan L, Yang N, Zeng J, Guo G, Li Q, Wang P, Zeng W, Zheng J: Response regulator KdpE contributes to Aeromonas dhakensis virulence. Aquaculture 2023, 568: 739298.

[13] Ling B, Feng W, Yang N, Fan L, Guo G, Li X, Zeng J, Zheng J: High incidence of multiple intI1 genomic gene cassettes in Aeromonas strains. Aquaculture 2023, 579: 740171.

[14] Rehman MNU, Dawar FU, Zeng J, Fan L, Feng W, Wang M, Yang N, Guo G, Zheng J: Complete genome sequence analysis of Edwardsiella tarda SC002 from hatchlings of Siamese crocodile. Frontiers in Veterinary Science 2023, 10: 1140655.

[15] 6. Li R, Ling B, Zeng J, Wang X, Yang N, Fan L, Guo G, Li X, Yan F, Zheng J: A nosocomial Pseudomonas aeruginosa ST3495 isolated from a wild Burmese python (Python bivittatus) with suppurative pneumonia and bacteremia in Hainan, China. Brazilian Journal of Microbiology 2023, 54(3): 2403-2412.

[16] Wang X, Pan J, Chen L, Li R, Han Y, Di Z, Ling B, Ahmad A, Yang N, Fan L et al: Prevalence, virulence-related genes and antimicrobial resistance of Aeromonas spp. from loach Misgurnus anguillicaudatus with skin ulcer and healthy controls in Southern China. Aquaculture 2022, 552: 738040.

[17] Zihao D, Jiping Z, Haiwen Z, Xin W, Guiying G, Youquan L, Qian H, Roushan L, Nuo Y, Lixia F et al: Natural outbreaks and molecular characteristics of Streptococcus agalactiae infection in farmed American bullfrog (Rana catesbeiana). Aquaculture 2022, 551:737885.

[18] Zeng J, Wang Y, Fan L, Yang N, Pan J, Han Y, Wang X, Li Q, Guo G, Zheng J et al: Novel Streptococcus uberis sequence types causing bovine subclinical mastitis in Hainan, China. J Appl Microbiol 2022, 132(3):1666-1674.

[19] Rehman MNUR, Wang Y, Pan J, Han Y, Yang N, Wang X, Fan L, Li Q, Yin F, Wang P et al: Histological and molecular characterization of Edwardsiella tarda infection in Siamese crocodile (Crocodylus siamensis) hatchlings. Aquaculture 2021, 535:736367.

[20] 10. Pu W, Wang Y, Yang N, Guo G, Li H, Li Q, Ur Rehman N, Zheng L, Wang P, Han S et al: Investigation of Streptococcus agalactiae using pcsB-based LAMP in milk, tilapia and vaginal swabs in Haikou, China. J Appl Microbiol 2020, 128(3):784-793.

[21] Liu H, Hou G, Wang P, Guo G, Wang Y, Yang N, Rehman MNU, Li C, Li Q, Zheng J et al: A double-locus scarless genome editing system in Escherichia coli. Biotechnology Letters 2020, 42(8):1457-1465.

七. 授权专利

[1] 郑继平, 曾纪锋, 李雪松, 郭桂英, 杨诺, 范丽霞. 达卡气单胞菌表面多糖合成基因缺失的突变株, 回补株及其构建方法和应用: ZL202410970620.1[P]. 2025-04-04.

[2] 郑继平, 郭桂英, 曾纪锋, 杨诺, 周楚新, 李迁. 一种无痕化双靶点基因组编辑系统: ZL201910201916.6[P]. 2022-09-23.

[3] 郑继平, 郭桂英, 曾纪锋, 杨诺, 李迁, 周楚新. 一种基于 pcsB 基因的无乳链球菌环介导等温扩增现场快检技术: ZL201910300214.3[P]. 2022-07-19.

[4] 范丽霞, 郑继平, 曾纪锋, 李雪松, 郭桂英, 杨诺. 鳄鱼源达卡气单胞菌 phoBR 和kdpE 基因缺失株、回补株及其构建方法和应用: ZL20231 1237566.1[P]. 2025-07-22.

[5] 杨诺, 郑继平, 曾纪锋, 李雪松, 郭桂英, 范丽霞, 李迁. 达卡气单胞菌 ugd 及 phoB 基因单双缺失突变株、回补株及其构建方法和应用: ZL20231 1310100.X[P]. 2025-05-23.

[6] 郭桂英, 郑继平, 曾纪锋, 李雪松, 杨诺, 范丽霞. 达卡气单胞菌 phoP 或 phoBR 单 突变株, 双突变株或其回补株及构建方法和应用: ZL20231 1207881.X[P]. 2025-01-24.

[7] 李雪松, 郑继平, 曾纪锋, 郭桂英, 范丽霞, 杨诺. 一种达卡气单胞菌突变株ΔarnA 和双突变株ΔugdΔarnA 及其构建方法和应用: ZL20231 1171120.3[P]. 2025-01-24.

[8] 李雪松, 郑继平, 张博学, 陈丹娜, 郭桂英, 范丽霞, 杨诺. 鳄鱼源贝莱斯芽孢杆菌 L09 株及其在水产养殖中的应用: ZL202411380863.6[P]. 2025-04-04. 技术转让: (专利实施 许可) (HDCG-202506001), 2025, 10万。

[9] Jiping Zheng, Xuesong Li, Guiying Guo, Lixia Fan, Nuo Yang, Jifeng Zeng. phoBR and kdpE gene deletion strains, replacement strains and construction methods and applications of Aeromonas dhakensis from crocodiles[P]. 南非专利:2023/11455. 2024-07-31.

[10] Guiying Guo, Jiping Zheng, Xuesong Li, Jifeng Zeng, Lixia Fan, Nuo Yang. An Aeromonas dhakensis mutant strain delta-arnA and a double mutant strain delta-ugd-arnA and a construction method and application thereof[P]. 南非专利: 2023/0998. 2024-05-30.

[11] Xuesong Li, Jiping Zheng, Guiying Guo, Jifeng Zeng, Nuo Yang, Lixia Fan. A single mutant strain, a double mutant strain or a complement strain of Aeromonas dhakensis phoP or phoBR, a construction method and an application thereof[P]. 南非专利: 2023/09891. 2024-05- 30.

八、 研究生招生

  博士：生物学、微生物学

  硕士：微生物学、遗传学

九、博士后招聘

    博士后：生物学、微生物学