姓 名：刘 征
职 称：研究员
导师类别：博士生导师
E-mail：liu-zheng@hainanu.edu.cn
一、个人基本情况
刘征，博士生导师，研究员，海南省拔尖人才。
二、教育工作情况
2012年于华中科技大学获得生物科学学士学位；2019年于华中科技大学获得生物医学工程博士学位，2019-2022于华中科技大学-武汉光电国家研究中心进行博士后研究。2023年加入海南大学。
三、科研情况
1. 国家自然科学基金面上项目，皮-肝轴中免疫细胞跨组织迁移的可视化研究及其功能初探，2024.01 - 2027.12, 在研，主持
2. 国家自然科学基金青年项目, 接触性超敏反应中炎症性单核/巨噬细胞迁移与活化的动态成像研究 2020.01 - 2022.12, 结题，主持
3. 国家自然科学基金重点项目，光学成像可视化研究肝转移过程中肿瘤异质性与微环境的时空变化 2024.01-2028-12，在研，主要骨干（第一参与人）
4. 国家自然科学基金重大研究计划，肝脏驻留γδT细胞的区域免疫可视化与细胞亚群全景图谱研究 2019.01-2022-12，结题，参与
5. 中国博士后科学基金面上项目, 2020.01-2022.12，结题，主持
四、研究领域
主要研究方向为免疫应答的光学可视化研究及基因编辑调控，建立了皮肤及肝脏等多种免疫可视化研究窗口及分子编辑技术，跨尺度探究了过敏性皮肤疾病、非酒精性脂肪肝炎等疾病过程中单核巨噬细胞迁移与活化的规律及机制。以第一作者或通讯作者在Nature Immunology, Trends in Biotechnology, Advanced Science, J Invest Dermatol, Communications Biology等期刊发表多篇论文。
五、社会兼职
海南省免疫学会常务理事
六、代表性成果
1. Mengli Xu†, Zheng Liu†,*, Qi Pan, Zhenzhen Cai, Xinlin Li, Songlin Huang, Xinru Wang, Yilun Xu, Jiayang Liu, Yujie Zhai, Jie yang, Zhan Fan, Yafang Lu, Lulu Gao, Yutong Han, Qingming Luo*, Zhihong Zhang*. Identification of Neuroprotective Liver Portal Area Macrophages Attenuating Hepatic Inflammation. Nature Immunology. Accept. 2025
2. Yafang Lu, Jialu Wang, Yilun Xu, Mengli Xu, Xinlin Li, Borui Li, Zhan Fan, Jinxin Liu, Zhenzhen Cai, Yuanzhe Zheng, Wenjing Wang, Jie Yang, Zhihong Zhang*, Zheng Liu*. Long-offset Paried Nicking-based Efficient and Precise Strategy for In Vivo Targeted Insertion. Trends in Biotechnology (Cell Press). Accept. 2025
3. Zhan Fan, Yafang Lu, Yilun Xu, Xinlin Li, Mengli Xu, Jinxin Liu, Zhenzhen Cai, Jiayang Liu, Jingping Su, Jialu Wang, Qingming Luo*,Zhihong Zhang*, Zheng Liu*. The crosstalk of monocyte-neutrophil in hair follicles regulates neutrophil transepidermal migration in contact dermatitis. Communications Biology. Accept. 2025
4. Zheng Liu†, Zhan Fan†, Jinxin Liu, Jialu Wang, Mengli Xu, Yafang Lu, Chenlu Han, Zhihong Zhang*, Melittin-carrying nanoparticle suppress T cell-driven immunity in a murine allergic dermatitis model. Advanced Science. 2023; Jan 13;e2204184;
5. Zheng Liu, Fei Yang, Hao Zheng, Zhan Fan, Sha Qiao, Lei Liu, Juan Tao, QingmingLuo*, ZhihongZhang*, Visualization of T cell-regulated monocyte clusters mediating keratinocyte death in acquired cutaneous immunity. J Invest Dermatol. 2018; 138：1328-1337 (封面文章).
6. Zheng Liu†, Mengli Xu†, Songlin Huang†, Qi Pan, Chong Liu, Fanxin Zeng, Zhan Fan, Yafang Lu, Jialu Wang, Jinxin Liu, Xinlin Li, Qingming Luo*, and Zhihong Zhang* Mesoscale visualization of three-dimensional microvascular architecture and immunocyte distribution in intact mouse liver lobes. Theranostics. 2022; 12(12):5418-5433. (封面文章)
7. Qiaoya Lin†, Zheng Liu†, Meijie Luo†, Hao Zheng, Sha Qiao, Chenlu Han, Deqiang Deng, Zhan Fan, Yafang Lu, Zhihong Zhang, Qingming Luo*. Simulation of DC–T cell encounters based on DC morphology and T cell motility in mouse lymph nodes under mTOR inhibition. Science China Life Sciences. 2019；62：1168–1177 .
8. Songlin Huang†, Borui Li†, Zheng Liu†, Mengli Xu, Dong Lin, Jiahong Hu, Dongjian Cao, Qi Pan, Jing Zhang, Jing Yuan, Qingming Luo*, Zhihong Zhang*. Three-dimensional mapping of hepatic lymphatic vessels and transcriptome profiling of the lymphatic endothelial cells in healthy and diseased livers. Theranostics. 2023; 13(2):639-658.
9. Jialu Wang, Yafang Lu, Ren Zhang, Zhenzhen Cai, Zhan Fan, Yilun Xu, Zheng Liu*, Zhihong Zhang*. Modulating and Imaging Macrophage Reprogramming for Cancer Immunotherapy. Phenomics. 2024 Jun 22;4(4):401-414.
10. Mengli Xu†, Zheng Liu†, Xinlin Li, Xinru Wang, Xuenan Yuan, Chenlu Han, Zhihong Zhang*. Three-dimensional structure of liver vessels and spatial distribution of hepatic immune cells. JIOHS. 2023. doi:10.1142/S1793545823300069.
